Health-Related Quality of Life among Patients with Oral Potentially Malignant Disorder and Oral Cancer in Malaysia

Raman, Sivaraj and Shafie, Asrul Akmal and Abraham, Mannil Thomas and Kiong, Shim Chen and Maling, Thaddius Herman and Rajendran, Senthilmani and Cheong, Sok Ching (2022) Health-Related Quality of Life among Patients with Oral Potentially Malignant Disorder and Oral Cancer in Malaysia. Archives of Orofacial Sciences, 17 (1). 101 -111. ISSN 1823-8602, DOI

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Presently there is a lack of health-related quality of life (HRQOL) measure and its corresponding utility values for oral cancer and oral potentially malignant disorders (OPMD). This limits patient-centered outcomes for cost-effectiveness evaluations. The study aimed to determine post-treatment HRQOL of patients and ascertained differences between OPMD, early and late-stage oral cancer. A crosssectional survey was conducted among patients in oral maxillofacial specialist clinics in two public tertiary hospitals. Consented participants were required to complete the EQ-5D-5L questionnaire with the EQ Visual Analogue System (VAS). Kruskal-Wallis test was used to explore differences in values between stages. Multiple linear regression was used to explore factors that influenced the HRQOL. A total of 50 OPMD and 52 oral cancer patients were surveyed. The mean EQ-5D-5L health utility values was 0.842 (n = 50, SD = 0.139), 0.822 (n = 10, SD = 0.150) and 0.626 (n = 42, SD = 0.310) for OPMD, early- and late-stage cancer, respectively. The mean values of the EQ-5D-5L index and EQ-VAS scale showed significant differences between groups and between early- and late-stage cancer with good discriminative properties. Results of the multiple linear regression indicated that ethnicity, income, residency, diagnosis, and treatment modality were able to significantly account for 25 of EQ-5D-5L utility values, F(10,91) = 3.83, p < 0.001, R2 = 0.360. Indian ethnicity, rural location, income less than RM4,360, late-stage cancer, and multi-modal therapies were all predictors of poorer HRQOL. This study evidenced disease severity and treatment modality to greatly impact the HRQOL of patients, in addition to socio-demographic factors such as ethnicity and income. © 2022. Penerbit Universiti Sains Malaysia. All Rights Reserved.

Item Type: Article
Funders: Ministry of Higher Education, Malaysia [Grant No: FRGS/1/2018/ SKK14/USM/02/1]
Uncontrolled Keywords: Inequality; Oral Cancer; Oral Potentially Malignant Disorders; Precancer; Quality of Life
Subjects: R Medicine > RK Dentistry > Oral surger
Divisions: Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 28 Dec 2023 06:59
Last Modified: 28 Dec 2023 06:59

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