Colonization of the newborn respiratory tract and its association with respiratory morbidity in the first 6 months of life: A prospective cohort study: Infant respiratory colonization

Nathan, Anna Marie and Chong, Kai Ning and Teh, Cindy Shuan Ju and Hng, Shih Ying and Eg, Kah Peng and De Bruyne, Jessie Anne and Muhamad, Anis Najwa and Adam, Quraisiah and Ahmad Zaki, Rafdzah and Razali, Nuguelis (2022) Colonization of the newborn respiratory tract and its association with respiratory morbidity in the first 6 months of life: A prospective cohort study: Infant respiratory colonization. International Journal of Infectious Diseases, 122. 712 – 720. ISSN 1201-9712, DOI

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Objectives: We aimed to determine the association between newborn bacterial colonization and infant respiratory morbidity in the first 6 months of life. Methods: This prospective study included healthy newborn infants. Nasopharyngeal swabs performed within 72 hours of delivery were analyzed using polymerase chain reaction. We assessed cumulative respiratory morbidity of infants at 6 months. Results: A total of 426 mother-infant pairs were recruited. In 53.3 (n = 225) of newborns, Streptococcus pneumoniae (46) and Staphylococcus aureus (7.3) were isolated. None had Haemophilus influenzae nor Moraxella catarrhalis. At the age of 6 months, 50.7 of infants had experienced respiratory symptoms, 25 had unscheduled doctor visits, and 10 were treated with nebulizers. Colonization with S. pneumoniae was associated with reduced risk of any respiratory symptom (adjusted odds ratio aOR 0.39, 95% confidence interval CI 0.16, 0.50), unscheduled doctor visits (aOR 0.35; 95% CI 0.18, 0.67), and nebulizer treatment (aOR 0.23, 95% CI 0.07, 0.72) at 6 months. Pregnancy-induced hypertension was also associated with increased need for nebulizer treatment (aOR 9.11, 95% CI 1.43, 58.1). Conclusion: Colonization of the newborn respiratory tract occurred in 53% of infants. S. pneumoniae was the most common organism, and this was associated with a reduced risk for respiratory morbidity at 6 months of life. © 2022 The Author(s)

Item Type: Article
Funders: Malaysian Thoracic Society, Malaysia, Universiti Malaya, RK-003-2020
Additional Information: Cited by: 0
Uncontrolled Keywords: Female; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Moraxella catarrhalis; Morbidity; Nasopharynx; Pregnancy; Prospective Studies; Respiratory System; Streptococcus pneumoniae; ampicillin; cefalexin; cefuroxime; clavulanic acid; Article; bacterial colonization; cohort analysis; controlled study; coughing; demography; DNA purification; female; Haemophilus influenzae; human; infant; longitudinal study; major clinical study; Malaysia; maternal exposure; maternal hypertension; Moraxella catarrhalis; morbidity; mother child relation; nasopharyngeal swab; newborn; polymerase chain reaction; pregnancy diabetes mellitus; prospective study; respiratory tract disease; rhinorrhea; Staphylococcus aureus; Streptococcus pneumoniae; urinary tract infection; microbiology; Moraxella catarrhalis; morbidity; nasopharynx; pregnancy; respiratory system
Subjects: R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine
Faculty of Medicine > Paediatrics Department
Faculty of Medicine > Social & Preventive Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Nov 2023 03:49
Last Modified: 24 Nov 2023 03:49

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