Acinetobacter baumannii: an overview of emerging multidrug-resistant pathogen

Gautam, Deepan and Dolma, Karma G. and Khandelwal, Bidita and Mitsuwan, Watcharapong and Mahboob, Tooba and Pereira, Maria de Lourdes and Nawaz, Muhammad and Wiart, Christophe and Ardebili, Abdollah and Siyadatpanah, Abolghasem and Ehtesham, Hamideh and Patra, Jayanta Kumar and Kwanhian, Wiyada and Nissapatorn, Veeranoot (2022) Acinetobacter baumannii: an overview of emerging multidrug-resistant pathogen. Medical Journal of Malaysia, 77 (3). pp. 357-370. ISSN 0300-5283,

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The emergence of infections caused by Acinetobacter baumannii, a multidrug-resistant bacterium, has been a concern worldwide. This bacterium is an important hospitalacquired pathogen that causes several diseases including ventilator-associated pneumonia, bloodstream infections, and meningitis. This study aimed to determine antibioticresistant mechanisms in the pathogenesis of A. baumannii and the alternative treatment strategies against it. The combined actions of outer membrane protein A, formation of a biofilm on biotic and abiotic surfaces, phospholipases C and D, metal homeostatic system, lipopolysaccharides, and verotoxins are relevant for virulence and pathogenesis. A. baumannii resists the broad-spectrum antibiotics by its mechanisms of resistance, such as β-lactamases, efflux pump, aminoglycoside modifying enzymes, permeability changes, and alternation of targets. In an attempt to overcome the resistance mechanisms, plant-derived compounds and a combination of the antibiotics and the plant phytocompounds have been focused. Nanoparticles synthesised with the plant extract have been studied extensively. Furthermore, we projected modern methods, including multi-omics analysis, to study insight into mechanisms of actions of antibiotics. The information suggested that the potential antibiotic mechanisms of A. baumannii could lead to an alternative treatment against A. baumannii infections. © 2022, Malaysian Medical Association. All rights reserved.

Item Type: Article
Funders: Fundação para a Ciência e a Tecnologia, Ministerio de Educación, Cultura y Deporte, Ministério da Ciência, Tecnologia e Ensino Superior [Grant No: LA/P/0006/2020], Walailak University
Uncontrolled Keywords: Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; beta-Lactamases; Drug Resistance, Multiple, Bacterial; Humans; amikacin; aminoglycoside; antibiotic agent; avibactam; beta lactamase; carbapenem; carbapenemase; carvacrol; cefepime; cephalosporinase; chebulagic acid; chitosan; ciprofloxacin; colistin; corilagin; curcumin; DNA 16S; doripenem; ellagic acid; epigallocatechin gallate; eravacycline; essential oil; extended spectrum beta lactamase; fusidic acid; gentamicin; glycerophospholipid; gold nanoparticle; imipenem; kanamycin; lipopolysaccharide; nanoparticle; oleanolic acid; outer membrane protein; outer membrane protein A; phospholipase C; phytochemical; rifampicin; silver nanoparticle; tigecycline; virulence factor; antiinfective agent; Acinetobacter; Acinetobacter baumannii; amplified fragment length polymorphism; antibacterial activity; antibiotic resistance; antibiotic sensitivity; antifungal activity; antimicrobial activity; apoptosis; artificial ventilation; bacteremia; bacterial virulence; bloodstream infection; chronic obstructive lung disease; Clostridium difficile infection; disk diffusion; DNA sequence; Enterococcus faecalis; Escherichia coli; folliculitis; gene ontology; hospitalization; human; mass spectrometry; matrix assisted laser desorption ionization time of flight mass spectrometry; matrix-assisted laser desorption-ionization mass spectrometry; meningitis; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; multidrug resistance; multilocus sequence typing; nonhuman; osteomyelitis; oxidative stress; photodynamic therapy; pneumonia; principal component analysis; protein carbonylation; restriction mapping; Review; sequence homology; Terminalia chebula; urinary tract infection; wound healing; wound infection; Acinetobacter infection; microbiology; multidrug resistance
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Oct 2023 02:01
Last Modified: 25 Oct 2023 02:01

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