General health of pregnant sprague-dawley rats and neonates’ small intestine morphology upon maternal bisphenol a exposure: A preliminary study

Zulkifli, Sarah and Nor, Noor Shafina Mohd and Kadir, Siti Hamimah Sheikh Abdul and Ranai, Norashikin Mohd and Kornain, Noor Kaslina Mohd and Rasdi, Zatilfarihiah and Zain, Wan Nor Izzah Wan Mohamad and Rahman, Amirah Abdul and Khan, Jesmine and Jalaludin, Muhammad Yazid (2022) General health of pregnant sprague-dawley rats and neonates’ small intestine morphology upon maternal bisphenol a exposure: A preliminary study. Malaysian Journal of Fundamental and Applied Sciences, 18 (2). 227 -236. ISSN 2289-5981, DOI

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Associations between xenoestrogen bisphenol A (BPA) and multiple types of diseases, including metabolic syndrome, have been recorded in various studies. However, certain subsets of the human population are particularly more vulnerable to BPA repercussions, such as pregnant women, neonates, and children. This study was conducted to investigate the effects of BPA exposure during pregnancy on the general health of mothers and the histopathology of neonates’ small intestines. Eighteen Sprague-Dawley rats were divided into three groups: control, vehicle Tween-80, and 5mg/kg/day BPA after positive mating was confirmed. Physiological parameters consisted of body weight, waist circumference, water, and food intake, and blood pressures were measured at pregnancy day -1 or 2, 7, and 14 to see whether BPA exposure could exert obesogenic impacts on pregnant rats. Newborns were sacrificed to collect blood plasma for BPA analysis and intestinal samples for histopathological examination. Maternal BPA exposure did not affect the physiological parameters of pregnant rats. The number of pups delivered per litter and the sex ratio of BPA offsprings was not significantly different to those of control and vehicle groups (p>0.05). Likewise, the small intestine morphology of BPA neonates was comparable to those of controls and vehicles (preserved structure and absence of inflammatory cells infiltration). The nonsignificant difference in plasma BPA levels of control and BPA-exposed mothers and neonates may explain these findings. Future longitudinal studies which include the dose-dependent impacts of BPA on pregnant mothers’ health and neonates’ small intestine would be more beneficial. © Copyright Zulkifli et al.

Item Type: Article
Funders: Ministry of Education, Malaysia [Grant No:600-IRMI/FRGS 5/3 (387/2019)], Ministry of Education, Malaysia [Grant No:600-IRMI/FRGS-RACER 5/3 (008/2019)]
Uncontrolled Keywords: Bisphenol A; Histopathology; Maternal exposure; Pregnancy’s health; Small intestine
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine > Paediatrics Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Oct 2023 04:48
Last Modified: 24 Oct 2023 04:48

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