The effects of lyophilised platelet-rich plasma in third molar extraction sockets and its surrounding tissues

Rengarajoo, Jonathan and Ngeow, Wei Cheong and Ibrahim, Norliza (2022) The effects of lyophilised platelet-rich plasma in third molar extraction sockets and its surrounding tissues. Journal of Taibah University Medical Sciences, 17 (2). 289 -296. ISSN 1658-3612, DOI

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Objective: To determine the effects of repeated placement of quantified lyophilised platelet-rich plasma (LPRP) on the soft and hard tissue components. Methods: Lyophilised platelet-rich plasma was topically placed, and later injected, into fresh sockets using the third molar surgical model, randomised according to the split-mouth approach. The control site received placebo. The application of LPRP was done intraoperatively, one month and two months postoperatively. The measured endpoints included post-operative pain, swelling, trismus, pocket depth at mid-distal adjacent second molar, soft tissue healing, and bone formation (which was assessed radiographically). Fifteen healthy young adults, aged between 21 and 35 years, visiting the Oral and Maxillofacial Surgery Clinic at the University of Malaya were recruited for this study. Results: There was no significant difference in post-operative pain, swelling size, trismus, and bone healing within their specific timelines during this study. However, the LPRP group showed significant reduction in pocket depth at the two-month post-operative period, suggesting that LPRP improves soft tissue healing. Conclusion: Soft tissue healing, measured as the change of periodontal pocket depth, showed significant reduction, suggesting the benefit of LPRP for soft tissue healing. However, bone regeneration and reduction of post-operative sequelae showed no improvement even after quantification and repeated LPRP application. © 2021 The Authors

Item Type: Article
Funders: University of Malaya Dental Postgraduate Research Fund [Grant No: DPRG/24/17], Stemtech International Sdn Bhd
Uncontrolled Keywords: Placebo; Polyglactin; Adult; Article; Bone regeneration; Chronic periodontitis; Clinical article; Controlled study; Female; Fracture healing; Freeze drying; Healing; Human; Human tissue; Male; Ossification; Postoperative pain
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Divisions: Faculty of Dentistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Nov 2023 02:34
Last Modified: 16 Nov 2023 02:34

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