Epidemiology, risk factors, and major outcomes in post kidney transplant infections at National Hospital Kandy: A cross-sectional, pilot study

Nayanamali, M.A. and Athapaththu, A. and Basnayake, B. and Gunarathne, Thalwaththe Gedara Nadeeka Shayamalie and Wazil, Abdul and Mahanama, R. and Thangarajah, Brammah and Nanayakkara, Nishantha (2022) Epidemiology, risk factors, and major outcomes in post kidney transplant infections at National Hospital Kandy: A cross-sectional, pilot study. Indian Journal of Transplantation, 16 (1). 77 – 83. ISSN 2212-0017, DOI https://doi.org/10.4103/ijot.ijot_132_20.

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Background: Postkidney transplant (PKT) infections are associated with significant morbidity and mortality, especially in the early posttransplant period. The type of infection, associated risk factors, and predicted outcomes of the infections are essential for targeted appropriate management. Scientific published data, especially in local settings, are lacking. This study was conducted to assess the epidemiology, risk factors, and major outcomes of PKT infections requiring hospitalization. Methods: This was a prospective observational study, conducted at the Nephrology and Transplant Unit, National Hospital Kandy, Sri Lanka, for a period of 2 months from December 1, 2018, to January 30, 2019. Results: A total of 38 infectious episodes were recorded in 35 kidney recipients. The most common type of infection was urinary tract infection (UTI) noted in 36.6 (n = 14) of cases. The most frequent organisms isolated were coliform (7.9, n = 3). Seven potential risk factors including age, gender, comorbidities, source of kidney, induction modality, enhancement therapy, and months after renal transplant were evaluated. Among those potential risk factors, age was significantly associated with gastrointestinal tract infections (P = 0.033). There was a significant association between the gender and the severity of infections (P = 0.047). Majority of patients discharged from the hospital following complete recovery. Three patients were offered intensive care, two developed acute renal failure requiring renal replacement therapy and one was expired. Conclusion: The most common type of infection in PKT patients is UTI. Patient's age is significantly associated with gastrointestinal infections. Large-scale studies warrant for adequately concluding risk factors, epidemiology, and outcomes. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

Item Type: Article
Funders: None
Additional Information: Cited by: 0
Uncontrolled Keywords: Basiliximab; C reactive protein; Hemoglobin; Immunoglobulin; Methylprednisolone; Rituximab; Acne vulgaris; Acute kidney failure; Adolescent; Adult; Aged; Article; Bacterial infection; Bacterium isolate; Clinical article; Coliform bacterium; Comorbidity; Cross-sectional study; Disease severity; Female; Fever; Gastrointestinal infection; Genital tract infection; Graft recipient; Hemoglobin blood level; Hospital admission; Hospital discharge; Hospitalization; human; Intensive care; Kidney graft rejection; Kidney transplantation; Male; Middle aged; Mycosis; National Early Warning Score; Neutrophil; Nonhuman; Observational study; Outcome assessment; Pilot study; Plasma exchange; Postoperative infection; Prospective study; Risk factor; Sri Lanka; Surgical infection; Urinary tract infection; Virus infection
Subjects: R Medicine > RD Surgery
Divisions: Faculty of Medicine > Nursing Science Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Nov 2023 07:04
Last Modified: 03 Dec 2023 02:16
URI: http://eprints.um.edu.my/id/eprint/43304

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