Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions

Ram, S. and Siar, C.H. (2005) Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions. International Journal of Oral and Maxillofacial Surgery, 34 (5). pp. 521-527. ISSN 0901-5027, DOI

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Chemiluminescence was evaluated as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions (PMELs) by comparing it against 1 tolonium chloride mouth rinse. Forty-six clinically identified lesions 14 primary squamous cell carcinoma (SCC), 26 PMELs and 6 benign lesions and five cases of normal oral mucosa from 40 subjects (inclusive of 10 previously treated SCC cases) were examined with a commercial chemiluminescent kit (Vizilite (R)) and tolonium chloride. Biopsy and histological verification of 31 lesions disclosed 14 SCC (45.2%), 10 epithelial dysplasias (32.3%), 5 lichen planus (16.1%) and 2 benign lesions (6.4%). For the remaining 15 lesions, a biopsy was not performed owing to patient's lack of consent or ill-health. The five cases of normal oral mucosa which tested negative for both tools were also not biopsied for ethical reasons. Sensitivity for Vizilite (R) and tolonium chloride was 100% and 70.3%, respectively; and specificity was 14.2% for Vizilite (R) and 25% for tolonium chloride. Their accuracy was 80.6% and 64.5%, respectively. Current findings suggest that chemiluminescence is a more reliable diagnostic tool than tolonium chloride in the detection of oral cancer and PMELs, and for follow-up of patients treated for the same.

Item Type: Article
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Uncontrolled Keywords: Chemiluminescence Vizilite((R)) tolonium chloride oral cancer PMEL squamous-cell carcinoma toluidine blue tolonium chloride dysplasia tongue rinse risk
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 09 Jan 2013 01:18
Last Modified: 09 Jan 2013 01:18

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