Renal Nano-drug delivery for acute kidney Injury: Current status and future perspectives

Geo, Hui Nee and Murugan, Dharmani Devi and Chik, Zamri and Norazit, Anwar and Foo, Yiing Yee and Leo, Bey Fen and Teo, Yin Yin and Syed Abdul Kadir, Sharifah Zamiah and Chan, Yinghan and Chai, Hann Juang and Medel, Maria and Abdullah, Nor Azizan and Johns, Edward J. and Vicent, Maria J. and Chung, Lip Yong and Kiew, Lik Voon (2022) Renal Nano-drug delivery for acute kidney Injury: Current status and future perspectives. Journal of Controlled Release, 343. pp. 237-254. ISSN 0168-3659, DOI

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Acute kidney injury (AKI) causes considerable morbidity and mortality, particularly in the case of post-cardiac infarction or kidney transplantation; however, the site-specific accumulation of small molecule reno-protective agents for AKI has often proved ineffective due to dynamic fluid and solute excretion and non-selectivity, which impedes therapeutic efficacy. This article reviews the current status and future trajectories of renal nanomedicine research for AKI management from pharmacological and clinical perspectives, with a particular focus on appraising nanosized drug carrier (NDC) use for the delivery of reno-protective agents of different pharmacological classes and the effectiveness of NDCs in improving renal tissue targeting selectivity and efficacy of said agents. This review reveals the critical shift in the role of the small molecule reno-protective agents in AKI pharmacotherapy -from prophylaxis to treatment -when using NDCs for delivery to the kidney. We also highlight the need to identify the accumulation sites of NDCs carrying reno-protective agents in renal tissues during in vivo assessments and detail the less-explored pharmacological classes of reno-protective agents whose efficacies may be improved via NDC-based delivery. We conclude the paper by outlining the challenges and future perspectives of NDC-based reno-protective agent delivery for better clinical management of AKI.

Item Type: Article
Funders: University of Malaya, Malaysia (Research University) [Grant No: GPF007C-2018], Spanish Government [Grant No: RTC-2017-6600-1; PID2019-108806RB-I00]
Uncontrolled Keywords: Nanoparticles; Nanocarriers; Polymeric drug carriers; Renal targeting; Reno-protective agent; Acute kidney injury
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Faculty of Science > Department of Chemistry
Faculty of Pharmacy
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Sep 2023 04:41
Last Modified: 18 Sep 2023 04:41

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