Associations between inflammation-related LL-37 with subgingival microbial dysbiosis in rheumatoid arthritis patients

Cheah, Chia Wei and Al-Maleki, Anis Rageh Mohammed and Vaithilingam, Rathna Devi and Vadivelu, Jamunarani and Sockalingam, Sargunan and Baharuddin, Nor Adinar and Bartold, Peter Mark (2022) Associations between inflammation-related LL-37 with subgingival microbial dysbiosis in rheumatoid arthritis patients. Clinical Oral Investigations, 26 (5). pp. 4161-4172. ISSN 14326981, DOI

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Objective This study investigated the subgingival microbial profile of rheumatoid arthritis (RA) patients and its associations with disease parameters and the inflammation-related antimicrobial peptide, LL-37. Methods RA and non-RA (NRA) patients were assessed for periodontal status and divided into periodontitis (CP), gingivitis (G), and healthy (H) groups. Subgingival plaque 16s rRNA gene sequencing data was processed and analyzed using the CLC Genomic Workbench (Qiagen). Bacterial diversity and co-occurrence patterns were examined. Differential abundance between groups was also investigated. Associations between bacterial genera with disease parameters and LL-37 levels were explored qualitatively using canonical correlation analysis. Results Subgingival microbial community clustered in CP status. Co-occurrence network in NRA-H was dominated by health-associated genera, while the rest of the networks' key genera were both health- and disease-associated. RA-CP displayed highly inter-generic networks with a statistically significant increase in periodontal disease-associated genera (p<0.05). In NRA-H, disease parameters and LL-37 were correlated positively with disease-associated genera while negatively with health-associated genera. However, in the remaining groups, mixed positive and negative correlations were noted with genera. Conclusion RA patients demonstrated subgingival microbial dysbiosis where the bacteria networks were dominated by health- and disease-associated genera. Mixed correlations with disease parameters and LL-37 levels were noted.

Item Type: Article
Uncontrolled Keywords: Inflammation; LL-37; Subgingival microbial; Dysbiosis; Rheumatoid arthritis
Subjects: R Medicine > R Medicine (General)
R Medicine > RK Dentistry
Divisions: Faculty of Medicine
Faculty of Medicine > Medicine Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 05 Oct 2023 07:03
Last Modified: 05 Oct 2023 07:03

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