Carica papaya leaf juice for dengue: A scoping review

Teh, Bee Ping and Ahmad, Norzahirah Binti and Mohamad, Saharuddin and Tan, Terence Yew Chin and Abd Razak, Mohd Ridzuan Bin Mohd and Afzan, Adlin Binti and Mohamed, Ami Fazlin Binti Syed (2022) Carica papaya leaf juice for dengue: A scoping review. Nutrients, 14 (8). ISSN 2072-6643, DOI

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The potential therapeutic effect of Carica papaya leaf juice has attracted wide interest from the public and scientists in relieving dengue related manifestations. Currently, there is a lack of evaluated evidence on its juice form. Therefore, this scoping review aims to critically appraise the available scientific evidence related to the efficacy of C. papaya leaf juice in dengue. A systematic search was performed using predetermined keywords on two electronic databases (PubMed and Google Scholar). Searched results were identified, screened and appraised to establish the association between C. papaya and alleviating dengue associated conditions. A total of 28 articles (ethnobotanical information: three, in vitro studies: three, ex vivo studies: one, in vivo study: 13, clinical studies: 10) were included for descriptive analysis, which covered study characteristics, juice preparation/formulations, study outcomes, and toxicity findings. Other than larvicidal activity, this review also reveals two medicinal potentials of C. papaya leaf juice on dengue infection, namely anti-thrombocytopenic and immunomodulatory effects. C. papaya leaf juice has the potential to be a new drug candidate against dengue disease safely and effectively.

Item Type: Article
Uncontrolled Keywords: Carica papaya; Papaya; Leaf; Juice; Dengue; Platelet; Phenolic; Flavonoid
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 11 Sep 2023 06:08
Last Modified: 11 Sep 2023 06:08

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