Microcystic adnexal carcinoma with mandibular bone marrow involvement - a case report with immunohistochemistry

Nagatsuka, H. and Rivera, R.S. and Gunduz, M. and Siar, C.H. and Tamamura, R. and Mizukawa, N. and Asaumi, J. and Nagai, N. (2006) Microcystic adnexal carcinoma with mandibular bone marrow involvement - a case report with immunohistochemistry. American Journal of Dermatopathology, 28 (6). pp. 518-522. ISSN 0193-1091, DOI https://doi.org/10.1097/01.dad.0000211511.52489.aa.


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Microcystic adnexal carcinoma is a rare, locally aggressive cutaneous neoplasm with a high probability of persistence locally but a low probability of metastasis. We report a case of a 69-year-old female patient with an indurated plaque at the mental region. Histologically, the tumor cells invaded the subcutaneous tissue and mandibular bone. The tumor consisted mainly of squamous and basaloid epithelial nests and cords embedded in a desmoplastic stroma. A few keratin-filled microcysts and ductal structures were also observed. Perineural encroachment was also noted but there was no mitosis, cytologic features of malignancy, or metastasis. The epithelial nests were positive to various cytokeratins except for CK20 and the lumina of the ductal structures were positive to carcinoembryonic antigen. Our results indicate that microcystic adnexal carcinoma consists of tumor cells capable of both follicular and eccrine differentiation. It is locally aggressive, extends far beyond its clinical presentation and may involve the bone. It may persist and remain asymptomatic for so many years without metastasis. A lifetime postsurgery monitoring is mandatory to ensure early and proper management.

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Additional Information: ISI Document Delivery No.: 172GR Times Cited: 5 Cited Reference Count: 42 Cited References: Abbate M, 2003, DERMATOL SURG, V29, P1035, DOI 10.1046/j.1524-4725.2003.29296.x Antley CA, 1999, J CUTAN PATHOL, V26, P48, DOI 10.1111/j.1600-0560.1999.tb01790.x APISARNTHANARAX P, 1984, ARCH DERMATOL, V120, P231, DOI 10.1001/archderm.120.2.231 Ban M, 2003, DERMATOLOGY, V207, P395, DOI 10.1159/000074122 Beer KT, 2005, STRAHLENTHER ONKOL, V181, P405, DOI 10.1007/s00066-005-1323-9 Billingsley EM, 1996, ARCH OTOLARYNGOL, V122, P179 BIRKBY CS, 1989, J DERMATOL SURG ONC, V15, P308 BURNS MK, 1994, J DERMATOL SURG ONC, V20, P429 Chiller K, 2000, ARCH DERMATOL, V136, P1355, DOI 10.1001/archderm.136.11.1355 CLEMENT CI, 2005, OPHTHAL PLAST RECONS, V2, P97 Cook TF, 1998, SEMIN CUTAN MED SURG, V17, P114, DOI 10.1016/S1085-5629(98)80005-9 COOPER PH, 1986, ARCH DERMATOL, V122, P261, DOI 10.1001/archderm.122.3.261 COOPER PH, 1985, AM J SURG PATHOL, V9, P422, DOI 10.1097/00000478-198506000-00004 COOPER PH, 1984, J AM ACAD DERMATOL, V10, P908, DOI 10.1016/S0190-9622(84)80445-4 Culhaci N, 2003, J ORAL MAXIL SURG, V61, P723, DOI 10.1053/joms.2003.50143 Elder DER, 1997, LEVERS HISTOPATHOLOG Friedman PM, 1999, J AM ACAD DERMATOL, V41, P225, DOI 10.1016/S0190-9622(99)70053-8 FUTRAN ND, 1992, OTOLARYNG HEAD NECK, V107, P457 GOLDSTEIN DJ, 1982, CANCER, V50, P566, DOI 10.1002/1097-0142(19820801)50:3<566::AID-CNCR2820500330>3.0.CO;2-Q KATO N, 1992, Journal of Dermatology (Tokyo), V19, P51 Khachemoune A, 2005, INT J DERMATOL, V44, P507, DOI 10.1111/j.1365-4632.2004.02581.x LEBOIT PE, 1993, J AM ACAD DERMATOL, V29, P609 Leibovitch I, 2005, J AM ACAD DERMATOL, V52, P295, DOI 10.1016/j.jaad.2004.10.868 LIPPER S, 1979, CANCER, V44, P157, DOI 10.1002/1097-0142(197907)44:1<157::AID-CNCR2820440127>3.0.CO;2-4 MCALVANY JP, 1994, J DERMATOL SURG ONC, V20, P767 MIYAMOTO T, 1990, DERMATOLOGICA, V180, P40 MURPHY GF, 1990, ATLAS TUMOR PATHOLOG NEWMAN L, 1986, BRIT J ORAL MAX SURG, V24, P448, DOI 10.1016/0266-4356(86)90061-6 Ohta M, 2004, DERMATOL SURG, V30, P957, DOI 10.1111/j.1524-4725.2004.30271.x Ohtsuka H, 2002, DERMATOLOGY, V204, P190, DOI 10.1159/000057880 Ongenae KC, 2001, DERMATOL SURG, V27, P979, DOI 10.1046/j.1524-4725.2001.01061.x Peterson CM, 2001, J AM ACAD DERMATOL, V45, P283, DOI 10.1067/mjd.2001.114298 Pujol RM, 1997, AM J DERMATOPATH, V19, P358, DOI 10.1097/00000372-199708000-00007 REQUENA L, 1990, CLIN EXP DERMATOL, V15, P222, DOI 10.1111/j.1365-2230.1990.tb02076.x ROBINSON ML, 1995, J ORAL MAXIL SURG, V53, P846, DOI 10.1016/0278-2391(95)90347-X RONGIOLETTI F, 1986, BRIT J DERMATOL, V115, P101, DOI 10.1111/j.1365-2133.1986.tb06226.x Schwarze HP, 2000, INT J DERMATOL, V39, P369, DOI 10.1046/j.1365-4362.2000.00841-2.x SEBASTIEN TS, 1993, J AM ACAD DERMATOL, V29, P840, DOI 10.1016/0190-9622(93)70251-N Snow S, 2001, DERMATOL SURG, V27, P401, DOI 10.1046/j.1524-4725.2001.00208.x Stein JM, 2003, HEAD NECK-J SCI SPEC, V25, P251, DOI 10.1002/hed.10167 UCHIDA N, 1993, DERMATOLOGY, V187, P119 YUH WTC, 1991, ANN OTO RHINOL LARYN, V100, P601 Nagatsuka, Hitoshi Santos Rivera, Rosario Gunduz, Mehmet Siar, Chong Huat Tamamura, Ryo Mizukawa, Nobuyoshi Asaumi, Junichi Nagai, Noriyuki Lippincott williams & wilkins Philadelphia
Uncontrolled Keywords: Microcystic adnexal carcinoma bone invasion mummohistochemistry electron microscopy mohs micrographic surgery radiation-therapy tumor differentiation invasion origin skin boy
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 09 Jan 2013 01:07
Last Modified: 09 Jan 2013 01:07
URI: http://eprints.um.edu.my/id/eprint/4292

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