Angioarchitecture of primary oral malignant melanomas

Lee, Y.J. and Nagai, N. and Siar, C.H. and Nakano, K. and Nagatsuka, H. and Tsujigiwa, H. and Roan, C.H. and Gunduz, M. (2002) Angioarchitecture of primary oral malignant melanomas. Journal of Histochemistry & Cytochemistry, 50 (11). pp. 1555-1562. ISSN 0022-1554,


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Angiogenesis is an essential process in the progression of malignant tumors. However, little is known of the angioarchitecture in primary oral malignant melanoma. We sought to determine this by the use of periodic acid-Schiff (PAS) stain, endothelial markers (CD34, CD105) and laminin, and by transmission electron microscopy in two cases. The results demonstrated that endothelium-lined vessels dominated the tumor microvasculature and these stained positively for PAS, laminin, and endothelial markers. Mosaic and tumor-lined vessels were infrequently encountered. Most PAS-positive patterned networks and loops ultrastructurally represented intratumor microhemorrhages that probably arose secondary to tumor vessel leakiness. Vascular channels of the vasculogenic mimicry type were rare. They stained for laminin but not for endothelial markers.

Item Type: Article
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Uncontrolled Keywords: Tumor microvasculature oral malignant melanoma mosaic vessels co-opted vessels vascular channels intracellular channels periodic acid-Schiff stain immunohistochemistry transmission electron microscopy vasculogenic mimicry endothelial-cells tumor angiogenesis mucosal melanoma blood-vessels cancer expression cavity lymphangiogenesis identification
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Ms Nursyafiqah Abd Malek
Date Deposited: 09 Jan 2013 01:02
Last Modified: 09 Jan 2013 01:02

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