Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium

Ogasawara, Ai and Noguchi, Ryo and Shigi, Takuya and Nugroho, Alfarius Eko and Hirasawa, Yusuke and Kaneda, Toshio and Tougan, Takahiro and Horii, Toshihiro and Hadi, A. Hamid A. and Morita, Hiroshi (2022) Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium. Journal of Natural Medicines, 76 (3). pp. 645-653. ISSN 1340-3443, DOI

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Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A-E (1-5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A-F (1-6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain.

Item Type: Article
Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [Grant No; JP 19K07152], JSPS KAKENHI, Japan [Grant No; JP 16K08309]
Uncontrolled Keywords: Pyranocoumarin; Coumarin; Calophyllum scriblitifolium; Antimalarial activity; Caloforines A-G
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 12 Oct 2023 07:20
Last Modified: 12 Oct 2023 07:20

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