Zymogen-poor acinic cell carcinoma of the soft palate with high-grade transformation

Kallarakkal, Thomas George and Ismail, Siti Mazlipah and Goh, Yet Ching (2022) Zymogen-poor acinic cell carcinoma of the soft palate with high-grade transformation. Malaysian Journal of Pathology, 44 (1). pp. 121-127. ISSN 0126-8635,

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Acinic cell carcinoma is an uncommon malignant salivary gland tumour accounting for approximately 6-7% of all salivary gland neoplasms. The key diagnostic feature of acinic cell carcinoma is the presence of acinar cell differentiation characterised by cytoplasmic zymogen secretory granules. This tumour shows a variety of growth patterns, including solid, microcystic, follicular and papillary cystic patterns. Acinic cell carcinoma is typically a cytologically low-grade malignancy. Acinic cell carcinomas with high-grade transformation (HGT) are exceedingly rare and are reported to have a more aggressive clinical course than conventional acinic cell carcinoma. This is a case report of this uncommon entity with high-grade transformation arising on the soft palate in a 64-year-old woman.

Item Type: Article
Funders: None
Uncontrolled Keywords: Acinic cell carcinoma; High-grade transformation; Soft palate
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Dentistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 12 Oct 2023 03:38
Last Modified: 12 Oct 2023 03:38
URI: http://eprints.um.edu.my/id/eprint/42305

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