Toxicological Effects of Technical Xylene Mixtures on the Female Reproductive System: A Systematic Review

Suaidi, Noor Asyikin and Mahdi Alshawsh, Mohammed Abdullah and Hoe, See-Ziau and Mokhtar, Mohd Helmy and Md Zin, Siti Rosmani (2022) Toxicological Effects of Technical Xylene Mixtures on the Female Reproductive System: A Systematic Review. Toxics, 10 (5). ISSN 2305-6304, DOI

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Technical xylene is a compound of massive production that is used in applications such as petrochemical and healthcare laboratories. Exposure to xylene can cause acute and chronic effects in humans and animals. Currently available studies regarding xylene's adverse effects with credible designs were dated almost twenty years ago. This systematic review summarizes the findings regarding the detrimental effects of technical xylene from human, animal, and in vitro studies. It recapitulated available studies with respect to the effects of xylene on the female reproductive system to stress the need for updating the current data and guidelines. Based on pre-specified criteria, 22 studies from journal databases exploring the toxic effects of xylene on menstruation, endocrine endpoints, fetal development, and reproductive functions were included for the review. It was found that related studies with a specific focus on the effects of technical xylene on the female reproductive system were insufficient. Therefore, further studies are necessary to update the existing data, thus improving the quality and reliability of risk assessment of exposure to xylene in pregnant women

Item Type: Article
Funders: Fundamental Research Grant Scheme Grant No:FRGS-FP113-2020]
Uncontrolled Keywords: Xylene; Female reproductive system; Reproductive toxicity; Endocrine disruption; Ovarian toxicity
Subjects: G Geography. Anthropology. Recreation > GE Environmental Sciences
Divisions: Faculty of Medicine
Faculty of Medicine > Physiology Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 10 Oct 2023 04:15
Last Modified: 10 Oct 2023 04:15

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