Vascular function in the aging human brain during muscle exertion

Zhu, Maijian and Lee, Tania Xu Yar and Hsieh, Yu-Wen and Lai, Li-Fan and Condello, Giancarlo and Donnelly, Cyril J. and Smith, Marc and Hamzah, Sareena Hanim and Lim, Boon-Hooi and Huang, Chih-Yang and Chi, Nai-Fang and Kuo, Chia-Hua (2022) Vascular function in the aging human brain during muscle exertion. Aging-us, 14 (9). pp. 3910-3920. ISSN 1945-4589, DOI

Full text not available from this repository.


To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) aged 20-88 y. The amplitude of cerebral hemodynamic fluctuation was reflected by converting 300 values of % oxygen saturation and hemoglobin of each 30-second phase to standard deviation as indicatives of brain oxygenation variability (BOV) and brain hemodynamic variability (BHV) for each participant. Both BOV (+21-72%) and BHV (+94-158%) increased during the maximal voluntary muscle exertions for all age levels (alpha < 0.05), suggesting an increased vascular recruitment to maintain oxygen homeostasis in the brain. Intriguingly, BHV was >100 folds for both resting and challenged conditions (alpha < 0.001) in >80% of adults aged above 50 y despite similar BOV compared with young age counterparts, indicating a huge cost of amplifying hemodynamic oscillation to maintain a stable oxygenation in the aging brain. Since vascular endothelial cells are short-lived, our results implicate a hemodynamic compensation to emergence of daily deficits in replacing senescent endothelial cells after age 50 y.

Item Type: Article
Funders: Body Composition Technologies Ltd Pte, University of Taipei, Taipei, Taiwan
Uncontrolled Keywords: Frailty; Vascular Function; Muscle Strength; Endothelial Function; NIRS
Subjects: S Agriculture > SK Hunting sports
Divisions: Faculty of Sports and Exercise Science (formerly known as Centre for Sports & Exercise Sciences)
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Oct 2023 01:56
Last Modified: 17 Oct 2023 01:56

Actions (login required)

View Item View Item