An agonist of the CXCR4 receptor is therapeutic for the neuroparalysis induced by Bungarus snakes envenoming

Stazi, Marco and Fabris, Federico and Tan, Kae Yi and Megighian, Aram and Rubini, Alessandro and Mattarei, Andrea and Negro, Samuele and D'Este, Giorgia and Lista, Florigio and Rossetto, Ornella and Tan, Choo Hock and Montecucco, Cesare (2022) An agonist of the CXCR4 receptor is therapeutic for the neuroparalysis induced by Bungarus snakes envenoming. Clinical and Translational Medicine, 12 (1). ISSN 2001-1326, DOI

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Snake envenoming is a neglected disease that, each year, causes>100000deathsintropicalandsub-tropical areas of the world and leaves>400 000 envenomed patients with permanent disabilities, with associated high social costs ( This is a dis-ease of poverty believed by experts to be under reported.1Moreover, snake envenoming strikes particularly in lower income and rural parts of the world where advanced hospital care may not be rapidly available to the envenomed patient. A major number of neuropathological snakebites are produced by snakes of the Bungarus genus widely distributedinAsia.2Their venoms induce a descending flaccid paralysis with respiratory failure and autonomic dysfunctions. A large reduction of the function of the neuromuscular junction (NMJ) can be recorded electrophysiologically within few hours from snakebite,2and death may occur by respiratory failure. Mechanically ventilated patients survive because the Bungarus neurotoxins do not kill motor neurons but induce a rapid degeneration limited to the axon terminals which is followed by as low regeneration requiring prolonged hospitalization(3–5weeks) and eventual recovery.2,3However, hospitalization with mechanical ventilation poses major problems in low-income countries associated with high costs and risks of in-hospital complications.

Item Type: Article
Funders: University of Padova
Uncontrolled Keywords: Snake envenoming; Europathological snakebites; Bungarus snakes; Venoms; Respiratory failure; Autonomic dys-functions
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RD Surgery
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Oct 2023 07:57
Last Modified: 16 Oct 2023 07:57

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