Interpreting the role of nuchal fold for fetal growth restriction prediction using machine learning

Teng, Lung Yun and Mattar, Citra Nurfarah Zaini and Biswas, Arijit and Hoo, Wai Lam and Saw, Shier Nee (2022) Interpreting the role of nuchal fold for fetal growth restriction prediction using machine learning. Scientific Reports, 12 (1). ISSN 2045-2322, DOI

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The objective of the study is to investigate the effect of Nuchal Fold (NF) in predicting Fetal Growth Restriction (FGR) using machine learning (ML), to explain the model's results using model-agnostic interpretable techniques, and to compare the results with clinical guidelines. This study used second-trimester ultrasound biometry and Doppler velocimetry were used to construct six FGR (birthweight < 3rd centile) ML models. Interpretability analysis was conducted using Accumulated Local Effects (ALE) and Shapley Additive Explanations (SHAP). The results were compared with clinical guidelines based on the most optimal model. Support Vector Machine (SVM) exhibited the most consistent performance in FGR prediction. SHAP showed that the top contributors to identify FGR were Abdominal Circumference (AC), NF, Uterine RI (Ut RI), and Uterine PI (Ut PI). ALE showed that the cutoff values of Ut RI, Ut PI, and AC in differentiating FGR from normal were comparable with clinical guidelines (Errors between model and clinical; Ut RI: 15%, Ut PI: 8%, and AC: 11%). The cutoff value for NF to differentiate between healthy and FGR is 5.4 mm, where low NF may indicate FGR. The SVM model is the most stable in FGR prediction. ALE can be a potential tool to identify a cutoff value for novel parameters to differentiate between healthy and FGR.

Item Type: Article
Funders: Fetal Care Centre, Jeju National University Hospital
Uncontrolled Keywords: Uterine artery doppler; Thickness; Pregnancy; Standards; Indexes
Subjects: Q Science > Q Science (General)
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Computer Science & Information Technology
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Oct 2023 03:32
Last Modified: 13 Oct 2023 03:32

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