Paramanantham, Yogaambikai and Chung, Ivy and Mohd Said, Nur Akmarina (2022) The role of tumour microenvironment-driven miRNAs in the chemoresistance of muscle-invasive bladder cancer-a review. Urologic Oncology-Seminars and Original Investigations, 40 (4). pp. 133-148. ISSN 1078-1439, DOI https://doi.org/10.1016/j.urolonc.2022.01.013.
Full text not available from this repository.Abstract
Successful treatment for muscle-invasive bladder cancer is challenged by the ability of cancer cells to resist chemotherapy. While enormous progress has been made toward understanding the divergent molecular mechanisms underlying chemoresistance, the heterogenous interplay between the bladder tumour and its microenvironment presents significant challenges in comprehending the occurrence of chemoresistance. The last decade has seen exponential interest in the exploration of microRNA (miRNA) as a tool in the management of chemoresistance. In this review, we highlight the miRNAs involved in the tumour microenvironment crosstalk that contributes to the chemoresistance in bladder cancer. Decrypting the role of miRNAs in the interplay beholds scope for future clinical translational application in managing the long-standing concerns of chemoresistance in muscle-invasive bladder cancer. (C) 2022 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | Malaysian Ministry of Higher Education: Fundamental Research Grant Scheme FRGS [Grant No: FP017-2016] |
| Uncontrolled Keywords: | Urinary bladder neoplasms; Tumour microenvironment; MicroRNAs; Drug resistance |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine Faculty of Pharmacy Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Oct 2023 01:21 |
| Last Modified: | 17 Oct 2023 01:21 |
| URI: | http://eprints.um.edu.my/id/eprint/42025 |
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