Signaling pathways and natural compounds in triple-negative breast cancer cell line

Dewi, Citra and Fristiohady, Adryan and Amalia, Riezki and Khairul Ikram, Nur Kusaira and Ibrahim, Sugeng and Muchtaridi, Muchtaridi (2022) Signaling pathways and natural compounds in triple-negative breast cancer cell line. Molecules, 27 (12). ISSN 1420-3049, DOI

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Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, having a poor prognosis and rapid metastases. TNBC is characterized by the absence of estrogen, progesterone, and human epidermal growth receptor-2 (HER2) expressions and has a five-year survival rate. Compared to other breast cancer subtypes, TNBC patients only respond to conventional chemotherapies, and even then, with limited success. Shortages of chemotherapeutic medication can lead to resistance, pressured index therapy, non-selectivity, and severe adverse effects. Finding targeted treatments for TNBC is difficult owing to the various features of cancer. Hence, identifying the most effective molecular targets in TNBC pathogenesis is essential for predicting response to targeted therapies and preventing TNBC cell metastases. Nowadays, natural compounds have gained attention as TNBC treatments, and have offered new strategies for solving drug resistance. Here, we report a systematic review using the database from Pubmed, Science Direct, MDPI, BioScince, Springer, and Nature for articles screening from 2003 to 2022. This review analyzes relevant signaling pathways and the prospect of utilizing natural compounds as a therapeutic agent to improve TNBC treatments in the future.

Item Type: Article
Funders: Academic Leadership Grant of Universitas Padjadjaran [Grant No:1959/UN6.3.1/PT.00/2022]
Uncontrolled Keywords: Triple-negative Breast Cancer (TNBC); Cell lines inhibitors; Natural compounds
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 17 Oct 2023 02:17
Last Modified: 17 Oct 2023 02:17

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