Cytokine profile in patients with multiple sclerosis following exercise: A systematic review of randomized clinical trials

Najafi, Parisa and Hadizadeh, Maryam and Cheong, Jadeera Phaik Geok and Mohafez, Hamidreza and Abdullah, Suhailah (2022) Cytokine profile in patients with multiple sclerosis following exercise: A systematic review of randomized clinical trials. International Journal of Environmental Research and Public Health, 19 (13). ISSN 1660-4601, DOI

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Multiple sclerosis (MS) is one of the most prevalent causes of nontraumatic neurological impairment in young adults. This review aims to determine the impact of exercise on cytokine and adipokine profile levels as inflammatory markers in MS patients across various exercise paradigms. We used specific keywords in PubMed, Web of Science, The Cochrane Library, and Scopus to find randomized clinical trials addressing the effects of physical activity and exercise training on inflammatory markers levels in MS patients. The majority of the research showed no considerable changes in IL-6 levels, while three studies reported declining levels after the intervention. Approximately half of the trials observed a change in TNF-alpha and IL-10 levels after exercise interventions, while the other half showed no meaningful changes. Other markers such as IL-17, IL-4, IL-12, adipokines, and BDNF showed fluctuations in levels. We found no universal agreement on the effects of different exercise training protocols on the serum level of inflammatory markers in patients with MS. More research is needed to fully identify the effects of exercise on cytokines in MS patients.

Item Type: Article
Funders: Fundamental Research Grant Scheme (FRGS) (Grant No: FRGS/1/2020/STG03/UM/02/7), Ministry of Education, Malaysia
Uncontrolled Keywords: Multiple sclerosis; Inflammatory markers; Demyelinating autoimmune diseases; Exercise; Rehabilitation; Cytokine; Interleukins; Tumor necrosis factor alpha
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine > Medicine Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Oct 2023 08:46
Last Modified: 19 Oct 2023 08:46

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