Inevitable interlinks between biological clock and metabolism in mammals

Subramanian, Perumalip and Jayapalan, Jaime Jacqueline and Abdul-Rahman, Puteri Shafinaz Akmar (2022) Inevitable interlinks between biological clock and metabolism in mammals. Biological Rhythm Research, 53 (8). pp. 1285-1298. ISSN 0929-1016, DOI

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A key perception of energy homeostasis is the recognition of a mutual regulation between biological clock and cell metabolism. For instance, the regular occurrences of appetite and satiety is not incessant over 24 h, but is instead organized temporally over the 24 h and the light/dark cycle. In mammals, the temporal regulation of metabolism, physiology and behaviour about 24 h is regulated by a complex system of manifold cellular clocks, synchronized via neuronal and hormonal cues by a master clock situated in the suprachiasmatic nuclei of the hypothalamus. Chronic disturbance of circadian rhythms, as seen in human shift-workers (up to 20% of the dynamic populace), has been linked with the advancement of numerous unfavourable mental and metabolic disturbances, suggesting that metabolic processes and biological clock are tightly linked with each other. Comprehension of the functional associations among circadian desynchronization and general health in animal model systems and humans, nevertheless, is still meagre. To sum up, this research topic covers a broad assortment of functional connections amid circadian rhythms and metabolism at molecular, cellular, tissue, organ and organism level.

Item Type: Article
Funders: None
Uncontrolled Keywords: Circadian; Metabolism; Clock genes; Glucose
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 20 Oct 2023 06:46
Last Modified: 20 Oct 2023 06:46

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