Chemical advances in therapeutic application of exosomes and liposomes

Chew, Boon Cheng and Liew, Fong Fong and Tan, Hsiao Wei and Chung, Ivy (2022) Chemical advances in therapeutic application of exosomes and liposomes. Current Medical Chemistry, 29 (25). pp. 4445-4473. ISSN 0929-8673, DOI

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Exosomes and liposomes are vesicular nanoparticles that can encapsulate functional cargo. The chemical similarities between naturally occurring exosomes and synthetic liposomes have accelerated the development of exosome mimetics as a therapeutic drug delivery platform under physiological and pathological environments. To maximise the applications of exosomes and liposomes in the clinical setting, it is essential to look into their basic chemical properties and utilise these characteristics to optimise the preparation, loading, modification and hybridisation. This review summarises the chemical and biological properties of both exosomal and liposomal systems as well as some of the challenges related to their production and application. This article concludes with a discussion on potential perspectives for the integration of exosomal and liposomal technologies in mapping better approaches for their biomedical use, especially in therapeutics.

Item Type: Article
Funders: Fundamental Research Grant Scheme, Ministry of Higher Education, Malaysia, FRGS/1/2019/SKK08/MAHSA/02/5
Uncontrolled Keywords: Exosome; Liposome; Biogenesis; Cargo; Hybridisation; Drug delivery
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine
Deputy Vice Chancellor (Research & Innovation) Office > Institute of Research Management and Services
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Nov 2023 11:50
Last Modified: 19 Nov 2023 11:50

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