Correlation of the GC-MS-based metabolite profile of Momordica charantia fruit and its antioxidant activity

Perumal, V and Khatib, A. and Ahmed, Q. U. and Uzir, B. F. and Abas, F. and Murugesu, S. and Saiman, Mohd Zuwairi and Primaharinastiti, R. and El-Seedi, H. (2022) Correlation of the GC-MS-based metabolite profile of Momordica charantia fruit and its antioxidant activity. International Food Research Journal, 29 (1). pp. 58-66. ISSN 1985-4668, DOI

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Momordica charantia or bitter melon (Cucurbitaceae) is a widely consumed edible fruit with strong antioxidant properties. Due to these properties, it has been commercialised by the natural product industries as a coadjutant in the treatment of various ailments attributable to the deleterious effects of oxidants. The present work aimed to evaluate the antioxidant activity of M. charantia fruit extracts made with different compositions of ethanol:water, and to identify the metabolites that are responsible for this activity. To this end, the fruit samples were extracted using six different concentrations of ethanol in water (0, 20, 40, 60, 80, and 100%). Gas chromatography-mass spectrometry (GC-MS) and multivariate data analysis (MVDA) were used to identify significant antioxidants. The 80% ethanol:water extract showed the most significant (p < 0.05) antioxidant activity when tested with the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) antioxidant assays. The multivariate data analysis revealed that the metabolites related to this antioxidant activity were gentiobiose, glucose, galactonic acid, palmitic acid, galactose, mannose, and fructose. (c) All Rights Reserved

Item Type: Article
Funders: International Islamic University Malaysia (Grant No: P-RIGS18-027-0027), Swedish Research Links grant scheme (Grant No: VR 2016-05885), Department of Molecular Biosciences, Wenner-Grens Institute, Stockholm University, Sweden
Uncontrolled Keywords: Antioxidants; DPPH; FRAP; Metabolomics; Momordica charantia
Subjects: Q Science > QH Natural history > QH301 Biology
S Agriculture > S Agriculture (General)
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Oct 2023 03:20
Last Modified: 25 Oct 2023 03:20

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