Rosetting responses of Plasmodium-infected erythrocytes to antimalarials

Lee, Wenn Chyau and Russell, Bruce and Lau, Yee Ling and Nosten, Francois and Renia, Laurent (2022) Rosetting responses of Plasmodium-infected erythrocytes to antimalarials. American Journal of Tropical Medicine and Hygiene, 106 (6). pp. 1670-1674. ISSN 0002-9637, DOI

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In malaria, rosetting is a phenomenon involving the cytoadherence of uninfected erythrocytes to infected erythrocytes (IRBC) harboring the late erythrocytic stage of Plasmodium spp. Recently, artesunate-stimulated rosetting has been demonstrated to confer a survival advantage to P. falciparum late-stage IRBC. This study investigated the rosetting response of P. falciparum and P. vivax clinical isolates to ex vivo antimalarial treatments. Brief exposure of IRBC to chloroquine, mefloquine, amodiaquine, quinine, and lumefantrine increased the rosetting rates of P. falciparum and P. vivax. Furthermore, the ex vivo combination of artesunate with mefloquine and piperaquine also resulted in increased the rosetting rates. Drug-mediated rosette-stimulation has important implications for the therapeutic failure of rapidly cleared drugs such as artesunate. However, further work is needed to establish the ramifications of increased rosetting rates by drugs with longer half-lifves, such as chloroquine, mefloquine, and piperaquine.

Item Type: Article
Funders: None
Uncontrolled Keywords: Malaria; Vivax
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Medicine > Parasitology Deparment
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 26 Oct 2023 08:59
Last Modified: 26 Oct 2023 08:59

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