Mechanisms linking vitamin D deficiency to impaired metabolism: An overview

Mohd Ghozali, Nurulmuna and Nelli, Giribabu and Salleh, Naguib (2022) Mechanisms linking vitamin D deficiency to impaired metabolism: An overview. International Journal of Endocrinology, 2022. ISSN 1687-8337, DOI

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Vitamin D deficiency is a common health problem worldwide. Despite its known skeletal effects, studies have begun to explore its extra-skeletal effects, that is, in preventing metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. The mechanisms by which vitamin D deficiency led to these unfavorable metabolic consequences have been explored. Current evidence indicates that the deficiency of vitamin D could impair the pancreatic beta-cell functions, thus compromising its insulin secretion. Besides, vitamin D deficiency could also exacerbate inflammation, oxidative stress, and apoptosis in the pancreas and many organs, which leads to insulin resistance. Together, these will contribute to impairment in glucose homeostasis. This review summarizes the reported metabolic effects of vitamin D, in order to identify its potential use to prevent and overcome metabolic diseases.

Item Type: Article
Funders: Universiti Malaya (Grant No: PV038-2019)
Uncontrolled Keywords: Inhibits oxidative stress; Serum 25-hydroxyvitamin D; Polycystic-ovary-syndrome; Insulin-receptor gene; Beta-cell mass; D supplementation; 1,25-dihydroxyvitamin D-3; Intracellular calcium; Glucose-metabolism; Double-blind
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Physiology Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 07 Nov 2023 06:16
Last Modified: 07 Nov 2023 06:16

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