Design strategies and prospects in developing wearable glucose monitoring system using printable organic transistor and microneedle: A review

Rezali, Fazliyatul Azwa Md and Soin, Norhayati and Wan Muhamad Hatta, Sharifah Fatmadiana and Daut, Mohamad Hazwan Mohd and Nouxman, Muhammad Hafizuddin Al-Helmy and Hussin, Hanim (2022) Design strategies and prospects in developing wearable glucose monitoring system using printable organic transistor and microneedle: A review. IEEE Sensors Journal, 22 (14). pp. 13785-13799. ISSN 1530-437X, DOI

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Diabetes mellitus is a worldwide leading disease that brings about fatal complications due to poor body glucose management which requires regular screening. With progressive evolution of healthcare monitoring system, high demand for wearable biosensors has efficiently bridged the gap between organic semiconductor devices and biological systems due to their flexibility and biocompatibility as enzyme-based transducing mechanism. In this work, significant features of existing glucose monitoring systems and integration components are evaluated to extend the fully integrated sensing platform with exciting potentials of organic thin-film transistor (OTFT) as electrochemical glucose sensor at low manufacturing process < 200 degrees C. This review highlights the design strategies and challenges in developing printable OTFT devices with low voltage and high on/off-current ratio > 10(6) by considering material configuration including nanomaterials, advanced printing techniques and functionalization for highly sensitive performance based on amperometric or potentiometric measurements. For sample extraction, the role of microneedle is critically discussed with their prospects to provide real-time diagnosis of interstitial fluid through correlation with blood glucose for long wear period. It can be concluded that this paper accentuates the potentials of printable OTFT biosensors and ISF sampling system based on microneedle by adapting the key design requirements and characteristics presented here for novel breakthrough of cost-effective, minimally invasive and self-monitoring flexible integrated glucose sensor system that conform to skin.

Item Type: Article
Funders: Collaborative Research in Engineering, Science and Technology Center (CREST), Malaysian Ministry of Higher Education, FRGS (Grant No: FRGS/1/2019/TK05/UM/02/4)
Uncontrolled Keywords: Flexible substrates; Enzymatic sensors; Hollow microneedles; Interstitial fluid; Organic semiconductors; Printed electronics; Thin-film transistors; Electrochemical
Subjects: Q Science > QC Physics
T Technology > TK Electrical engineering. Electronics Nuclear engineering
Divisions: Faculty of Engineering > Department of Electrical Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 08 Nov 2023 03:22
Last Modified: 08 Nov 2023 03:22

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