The association between diabetes and obesity with Dengue infections

Sekaran, S. D. and Liew, Z. M. and Yam, H. C. and Raju, Chandramathi Samudi (2022) The association between diabetes and obesity with Dengue infections. Diabetology & Metabolic Syndrome, 14 (1). ISSN 1758-5996, DOI

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Dengue, an arboviral disease is a global threat to public health as the number of Dengue cases increases through the decades and this trend is predicted to continue. Non-communicable diseases such as diabetes and obesity are also on an upward trend. Moreover, past clinical studies have shown comorbidities worsen the clinical manifestation of especially Severe Dengue. However, discussion regarding the underlying mechanisms regarding the association between these comorbidities and dengue are lacking. The hallmark of Severe Dengue is plasma leakage which is due to several factors including presence of pro-inflammatory cytokines and dysregulation of endothelial barrier protein expression. The key factors of diabetes affecting endothelial functions are Th1 skewed responses and junctional-related proteins expression. Additionally, obesity alters the lipid metabolism and immune response causing increased viral replication and inflammation. The similarity between diabetes and obesity individuals is in having chronic inflammation resulting in endothelial dysfunction. This review outlines the roles of diabetes and obesity in severe dengue and gives some insights into the plausible mechanisms of comorbidities in Severe Dengue.

Item Type: Article
Funders: UCSI University (Grant No: REIG-FHMS-2021_31)
Uncontrolled Keywords: Diabetes; Obesity; Dengue; Endothelium; Th-1 cytokines; Junctional proteins; Adhesion molecules
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 08 Nov 2023 04:12
Last Modified: 08 Nov 2023 04:12

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