Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease

Tsui, Ka Chun and Roy, Jaydeep and Chau, Sze Chun and Wong, Kah Hui and Shi, Lei and Poon, Chi Him and Wang, Yingyi and Strekalova, Tatyana and Aquili, Luca and Chang, Raymond Chuen-Chung and Fung, Man-Lung and Song, You-qiang and Lim, Lee Wei (2022) Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease. Frontiers in Aging Neuroscience, 14. ISSN 1663-4365, DOI https://doi.org/10.3389/fnagi.2022.964336.

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Alzheimer's disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (A beta) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of A beta plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High A beta plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of A beta plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of A beta plaques were located in the amygdala, and the cerebellum; but no A beta plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of A beta plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of A beta deposition in the brain and its inter-regional correlation. This suggests an association between A beta plaque deposition and specific brain regions in AD pathogenesis.

Item Type: Article
Funders: None
Uncontrolled Keywords: Alzheimer's disease; Amyloid-beta (AB); Morphology; Neuroanatomy; 5xFAD; Dementia
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RL Dermatology > Pathological anatomy
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Nov 2023 02:09
Last Modified: 27 Nov 2023 02:09
URI: http://eprints.um.edu.my/id/eprint/41591

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