Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review

Hannh, R. and Ramani, Pratibha and Tilakaratne, Wanninayake Mudiyanselage and Sukumaran, Gheena and Ramasubramanian, Abilasha and Krishnan, Reshma Poothakulath (2022) Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris-A review. Oral Diseases, 28 (7). pp. 1760-1769. ISSN 1354-523X, DOI

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Pemphigus vulgaris is an autoimmune blistering disease with an increased potential for mortality. The epithelium is key in understanding the pathobiology as it is specialized to perform functions like mechanical protection, immunological defense, and proprioception. In order to perform these array of functions, epithelial integrity is important. This integrity is maintained by a host of molecules which orchestrate the ability of the keratinocytes to function as a single unit. Desmoglein 3 antibodies formed in genetically susceptible individuals are known to cause the disruption of the intact oral mucosa leading to the formation of blisters in pemphigus vulgaris patients. However, there are underlying complex triggering pathways leading to the clinical disease. The aim of the review is to congregate and critically appraise the various triggering pathways which contribute toward the pathobiology of pemphigus vulgaris. Articles relevant to the pathobiology of pemphigus vulgaris were identified from various search databases till the year 2020. The pathogenesis of pemphigus vulgaris is complex, and it involves an in-depth understanding of the various predisposing factors, provoking factors, and progression mechanisms. Congregation of the various triggering pathways will open our minds to understand pemphigus vulgaris better and in turn develop a reliable treatment in the near future.

Item Type: Article
Funders: None
Uncontrolled Keywords: Apoptolysis; Autoimmune disease; Desmoglein; Desmosomes; Pemphigus vulgaris; Vesiculobullous lesion
Subjects: R Medicine > RK Dentistry > Oral surger
Divisions: Faculty of Dentistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 06 Nov 2023 03:04
Last Modified: 06 Nov 2023 03:04

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