OFF-period purposeless groaning in Parkinsonism

Agarwal, Vikash and Rajan, Jeyalakshmi and Ramli, Norlisah and Santiago, Cecilia and Jasti, Dushyanth B. and Tan, Ai Huey and Lim, Shen Yang (2022) OFF-period purposeless groaning in Parkinsonism. Neurology India, 70 (3). pp. 1232-1234. ISSN 0028-3886, DOI

Full text not available from this repository.


Purposeless groaning is primarily encountered in patients with progressive supranuclear palsy and has also been reported to occur in advanced Parkinson's disease (PD). Objective: We describe a case of pronounced purposeless groaning occurring as a medication OFF-period nonmotor phenomenon in PD. To our knowledge, this has not been previously reported in the literature. Methods and Materials: We describe and provide video documentation of a patient with moderately advanced PD and motor fluctuations, in whom OFF-period groaning was reported by the family and observed during clinic consultations to be a prominent feature, occupying approximately 40% of his OFF periods as calculated from his PD diary. Results and Conclusions: Although rare, OFF-period purposeless groaning in PD can be very disruptive and add significantly to caregiver burden. It is postulated to be a disinhibitory and perseverative behavior related to overactivation of the cingulo-periaqueductal circuit; further study is needed to delineate the underlying pathophysiological mechanisms.

Item Type: Article
Uncontrolled Keywords: Groaning; Nonmotor fluctuations; Parkinson's disease; Vocalizations
Subjects: R Medicine
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Sep 2023 02:29
Last Modified: 25 Sep 2023 02:29

Actions (login required)

View Item View Item