Kappaphycus alvarezii compound powder prevents chemotherapy-induced intestinal mucositis in BALB/c mice

Zhang, Qing and Zhou, Sainan and Lim, Phaik Eem and Wei, Biqian and Xue, Changhu and Xue, Yong and Tang, Qingjuan (2022) Kappaphycus alvarezii compound powder prevents chemotherapy-induced intestinal mucositis in BALB/c mice. Nutrition and Cancer-An International Journal, 74 (10). pp. 3735-3746. ISSN 0163-5581, DOI https://doi.org/10.1080/01635581.2022.2089699.

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This study aimed to formulate Kappaphycus alvarezii compound powder containing Kappaphycus alvarezii powder (KP), cooked sorghum powder (SP), and longan powder (LP); which was evaluated for its therapeutic effects against chemotherapy-induced intestinal mucosal injury (CIMI). Based on rheological properties, sensory evaluation, and antioxidant activity and using single factor and response surface methodology, the optimal formula to develop the compound powder was determined to be 35% KP, 30% SP, 5% LP, and 30% xylitol. Thereafter, the efficacy of the compound powder was tested by feeding BALB/c mice with diets supplemented with the Kappaphycus alvarezii compound powder (3% and 5%) for 14 consecutive days. The chemotherapeutic drug 5-fluorouracil was intraperitoneally injected (50 mg/kg) in the mice to induce CIMI for the last three consecutive days. Compared to the CIMI mice, those fed 5% Kappaphycus alvarezii compound powder (HC) showed significantly improved the intestinal injury, increased mucin-2 secretion, and reduced TNF-alpha, IL-1 beta, IL-6, LT, and COX-2 levels. Furthermore, HC intake significantly reduced the Firmicutes-to-Bacteroidetes ratio, promoted the growth of beneficial bacteria, such as Alloprevotella, and inhibited the growth of harmful bacteria, such as Clostridium. In conclusion, HC has a protective effect against CIMI and provides a novel dietary strategy for patients undergoing chemotherapy.

Item Type: Article
Funders: key Research and Development Program of Shandong Province [2019GHY112058], National Key R&D Program of China [2018YFC0311201]
Uncontrolled Keywords: Oxidative stress; Induced-colitis; Gut microbiota; Polysaccharides
Subjects: R Medicine
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Institute of Ocean and Earth Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 22 Sep 2023 07:20
Last Modified: 22 Sep 2023 07:20
URI: http://eprints.um.edu.my/id/eprint/41440

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