Cytotoxic lesions of the corpus callosum after COVID-19 vaccination

Ohara, Hiroya and Shimizu, Hironori and Kasamatsu, Takehito and Kajita, Akihiro and Uno, Kenji and Lai, Khin Wee and Vellingiri, Balachandar and Sugie, Kazuma and Kinoshita, Masako (2022) Cytotoxic lesions of the corpus callosum after COVID-19 vaccination. Neuroradiology, 64 (10). pp. 2085-2089. ISSN 0028-3940, DOI

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A 23-year-old previously healthy man (Patient 1) and a 33-year-old woman with a past history of depression (Patient 2) developed neurological symptoms approximately 1 week after receipt of the first COVID-19 mRNA vaccination and deteriorated over the next week. Patient 1 reported nausea, headache, a high fever, and retrograde amnesia. Patient 2 reported visual disturbance, headache, dysarthria, a left forearm tremor, dysesthesia of the mouth and distal limbs, and visual agnosia. PCR test results for SARS-CoV-2 were negative. Complete blood cell count, biochemistry, and antibody test and cerebrospinal fluid test findings were unremarkable. Diffusion-weighted and fluid-attenuated inversion recovery MRI of the brain showed a high signal intensity lesion at the midline of the splenium of the corpus callosum compatible with cytotoxic lesions of the corpus callosum (CLOCCs). High-dose intravenous methylprednisolone improved their symptoms and imaging findings. CLOCCs should be considered in patients with neurological manifestation after COVID-19 vaccination.

Item Type: Article
Funders: JPJSBP [120217720]
Uncontrolled Keywords: Coronavirus disease 2019; COVID-19; Cytotoxic lesions of the corpus callosum; Mild encephalitis; Encephalopathy with reversible splenial lesion; COVID-19 mRNA vaccine
Subjects: R Medicine
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 22 Sep 2023 03:14
Last Modified: 22 Sep 2023 03:14

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