Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity

Abd Rani, Nur Zahirah and Lee, Yean Kee and Ahmad, Sarfraz and Meesala, Ramu and Abdullah, Iskandar (2022) Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity. Marine Drugs, 20 (9). ISSN 1660-3397, DOI https://doi.org/10.3390/md20090579.

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A marine natural product possesses a diverse and unique scaffold that contributes to a vast array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine natural products. These rare skeletons exhibit a wide range of biological applications, but their synthetic approaches are still limited. Various stereochemical assignments of the compounds remain unresolved. Batzelladine and ptilocaulins are an area of high interest in research on tricyclic guanidine alkaloids. In addition, mirabilins and netamines are among the other tricyclic guanidine alkaloids that contain the ptilocaulin skeleton. Due to the different structural configurations of batzelladine and ptilocaulin, these two main skeletons are afforded attention in many reports. These two main skeletons exhibit different kinds of compounds by varying their ester chain and sidechain. The synthetic approaches to tricyclic guanidine alkaloids, especially the batzelladine and ptilocaulin skeletons, are discussed. Moreover, this review compiles the first and latest research on the synthesis of these compounds and their bioactivities, dating from the 1980s to 2022.

Item Type: Article
Funders: Ministry of Education, Malaysia [FP030-2019A]
Uncontrolled Keywords: Marine sponges; Tricyclic guanidine; Guanidine alkaloids; Batzelladines; Ptilocaulins; Netamines; Mirabilins; Bioactivities; Synthesis
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Sep 2023 06:38
Last Modified: 18 Sep 2023 06:38
URI: http://eprints.um.edu.my/id/eprint/41306

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