Integrase deficient lentiviral vector: Prospects for safe clinical applications

Yew, Chee-Hong Takahiro and Gurumoorthy, Narmatha and Nordin, Fazlina and Tye, Gee Jun and Zaman, Wan Safwani Wan Kamarul and Tan, Jun Jie and Ng, Min Hwei (2022) Integrase deficient lentiviral vector: Prospects for safe clinical applications. PeerJ, 10. ISSN 2167-8359, DOI

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HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic materials into the targeted cells among many viral vectors. Genetic material transduced by lentiviral vector is integrated into the cell genome to introduce new functions, repair defective cell metabolism, and stimulate certain cell functions. Various measures have been administered in different generations of lentiviral vector systems to reduce the vector's replicating capabilities. Despite numerous demonstrations of an excellent safety profile of integrative lentiviral vectors, the precautionary approach has prompted the development of integrase-deficient versions of these vectors. The generation of integrase-deficient lentiviral vectors by abrogating integrase activity in lentiviral vector systems reduces the rate of transgenes integration into host genomes. With this feature, the integrase-deficient lentiviral vector is advantageous for therapeutic implementation and widens its clinical applications. This short review delineates the biology of HIV-1-erived lentiviral vector, generation of integrase-deficient lentiviral vector, recent studies involving integrase-deficient lentiviral vectors, limitations, and prospects for neoteric clinical use.

Item Type: Article
Funders: Ministry of Education, Malaysia [FRGS/1/2020/SKK06/UKM/03/4], Universiti Kebangsaan Malaysia through the Faculty of Medicine grant [FF-2020-327]
Uncontrolled Keywords: Integrase-deficient lentiviral vector; Gene therapy; Immunization; Cell Reprogramming; Cell death
Subjects: R Medicine
R Medicine > R Medicine (General)
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Aug 2023 04:00
Last Modified: 25 Aug 2023 04:00

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