Retrograde axonal transport of poliovirus and EV71 in motor neurons

Ohka, Seii and Tan, Soon Hao and Kaneda, Shohei and Fujii, Teruo and Schiavo, Giampietro (2022) Retrograde axonal transport of poliovirus and EV71 in motor neurons. Biochemical and Biophysical Research Communications, 626. pp. 72-78. ISSN 0006-291X, DOI

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Poliovirus (PV) can spread through neural pathway to the central nervous system and replicates in motor neurons, which leads to poliomyelitis. Enterovirus 71 (EV71), which is closely related to PV, is one of the causative agents of hand-foot-and-mouth disease and can cause severe neurological diseases similar to poliomyelitis. Since PV is similar to EV71 in its motor neurotoxicity, we tried to understand if the results obtained with PV are of general applicability to EV71 and other viruses with similar characteristics. Using microfluidic devices, we demonstrated that both PV capsid and the PV genome undergo axonal retro-grade transport with human PV receptor (hPVR), and the transported virus replicated in the soma of hPVR-expressing motor neurons. Similar to PV in hPVR-transgenic (Tg) mice, neural pathway ensuring spreading of EV71 has been shown in adult human scavenger receptor class B, member 2 (hSCARB2)-Tg mice. We have validated this finding in microfluidic devices by showing that EV71 is retrogradely transported together with hSCARB2 to the cell body where it replicates in an hSCARB2-dependent manner.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (

Item Type: Article
Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science [25460583], Naito Memorial Foundation
Uncontrolled Keywords: EV71; Poliovirus; Axonal transport; Transgenic mice; Micro fluidic devices
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Aug 2023 03:52
Last Modified: 25 Aug 2023 03:52

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