Dzulkeflee, Rashidi and Leong, Kok Hoong and Ogawa, Satoshi and Bignon, Jerome and Chan, Mun Chiang and Kong, Kin Weng (2022) Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer. Biochemical Pharmacology, 205. ISSN 0006-2952, DOI https://doi.org/10.1016/j.bcp.2022.115262.
Full text not available from this repository.Abstract
The role of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) has been vastly studied over the last decade. This has led to the rapid development of many generations of EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, patients treated with third-generation TKIs (osimertinib, avitinib and rociletinib) targeting the EGFR T790M mutation have shown emerging resistances and relapses. Therefore, further molecular understanding of NSCLC mutations, bypass signalling, tumour microenvironment and the existence of cancer stem cells to overcome such resistances is warranted. This will pave the way for designing novel and effective chemotherapies to improve patients' overall survival. In this review, we provide an overview of the multifaceted mechanisms of resistance towards EGFR-TKIs, as well as the challenges and perspectives that should be addressed in strategising chemotherapeutic treatments to overcome the ever-evolving and adaptive nature of NSCLC.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia [FRGS/1/2019/SKK09/UM/02/1], Universiti Malaya [RP035-17AFR] |
| Uncontrolled Keywords: | Lung cancer; NSCLC; EGFR-TKI; Cancer stem cells; Natural products |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 27 Sep 2023 03:12 |
| Last Modified: | 27 Sep 2023 03:12 |
| URI: | http://eprints.um.edu.my/id/eprint/40814 |
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