Escaping cell death via TRAIL decoy receptors: A systematic review of their roles and expressions in colorectal cancer

Jong, Kelly Xue Jing and Mohamed, Elsa Haniffah Mejia and Ibrahim, Zaridatul Aini (2022) Escaping cell death via TRAIL decoy receptors: A systematic review of their roles and expressions in colorectal cancer. Apoptosis, 27 (11-12). pp. 787-799. ISSN 1360-8185, DOI

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The development of targeted therapy such as tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-based therapy has gained increasing attention as a promising new approach in cancer therapy. TRAIL specifically targets cancer cells while sparing the normal cells, thus, limiting the known side effects of the majority anti-cancer therapies. As more extensive research and clinical trials are conducted, resistance to TRAIL molecule has become one of the significant issues associated with the failure of TRAIL in treating colorectal cancer (CRC). To date, the exact mechanism by which TRAIL resistance may have occurred remains unknown. Interestingly, recent studies have revealed the critical role of the TRAIL decoy receptor family; consisting of decoy receptor 1 (DcR1; also known as TRAIL-R3), decoy receptor 2 (DcR2; also known as TRAIL-R4), and osteoprotegerin (OPG) in driving TRAIL resistance. This review highlights the expression of the decoy receptors in CRC and its possible association with the reduction in sensitivity towards TRAIL treatment based on the currently available in vitro, in vivo, and human studies. Additionally, discrepancies between the outcomes from different research groups are discussed, and essential areas are highlighted for future investigation of the roles of decoy receptors in modulating TRAIL-induced apoptosis. Overcoming TRAIL resistance through modulating the expression(s) and elucidating the role(s) of TRAIL decoy receptors hold great promise for TRAIL-based therapies to be extensively explored in treating human cancers including CRC.

Item Type: Article
Funders: MAKNA Cancer Research Award [PV001-2021]
Uncontrolled Keywords: Colorectal cancer; Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL); Apoptosis; Decoy receptor; Osteoprotegerin (OPG); Targeted therapy
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 Sep 2023 04:32
Last Modified: 27 Sep 2023 04:32

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