Immune checkpoint molecules and glucose metabolism in HIV-Induced T cell exhaustion

Chan, Yee Teng and Cheong, Heng Choon and Tang, Ting Fang and Rajasuriar, Reena and Cheng, Kian-Kai and Looi, Chung Yeng and Wong, Won Fen and Kamarulzaman, Adeeba (2022) Immune checkpoint molecules and glucose metabolism in HIV-Induced T cell exhaustion. Biomedicines, 10 (11). ISSN 2227-9059, DOI

Full text not available from this repository.


The progressive decline of CD8(+) cytotoxic T cells in human immunodeficiency virus (HIV)-infected patients due to infection-triggered cell exhaustion and cell death is significantly correlated with disease severity and progression into the life-threatening acquired immunodeficiency syndrome (AIDS) stage. T cell exhaustion is a condition of cell dysfunction despite antigen engagement, characterized by augmented surface expression of immune checkpoint molecules such as programmed cell death protein 1 (PD-1), which suppress T cell receptor (TCR) signaling and negatively impact the proliferative and effector activities of T cells. T cell function is tightly modulated by cellular glucose metabolism, which produces adequate energy to support a robust reaction when battling pathogen infection. The transition of the T cells from an active to an exhausted state following pathogen persistence involves a drastic change in metabolic activity. This review highlights the interplay between immune checkpoint molecules and glucose metabolism that contributes to T cell exhaustion in the context of chronic HIV infection, which could deliver an insight into the rational design of a novel therapeutic strategy.

Item Type: Article
Funders: Malaysian Ministry of Higher Education Fundamental Research Grant Scheme FRGS/1/2018/SKK11/UM/01/1, FRGS/1/2022/SKK12/UM/02/34
Uncontrolled Keywords: CTLA-4; HIV; Glucose; Metabolism; PD-1; T cell exhaustion
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine
Faculty of Medicine > Medicine Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 16 Oct 2023 06:42
Last Modified: 24 Oct 2023 03:40

Actions (login required)

View Item View Item