Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules' fifth labour

Sulaiman, Mazdida and Zarubaev, Vladimir and Samudi, Chandramathi and Rahmatullah, Mohammed and Jannat, Khoshnur and Paul, Alok and Rajagopal, Mogana and Salvaraj, Malarvili and Nissapatorn, Veeranoot and Suleiman, Monica and Butler, Mark and Wiart, Christophe (2022) Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules' fifth labour. Pharmaceutical Biology, 60 (1). pp. 2049-2087. ISSN 1388-0209, DOI

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Context The emergence of zoonotic viruses in the last decades culminating with COVID-19 and challenges posed by the resistance of RNA viruses to antiviral drugs requires the development of new antiviral drugs. Objective This review identifies natural products isolated from Asian and Pacific medicinal plants with in vitro and in vivo antiviral activity towards RNA viruses and analyses their distribution, molecular weights, solubility and modes of action. Materials and methods All data in this review was compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem and library search from 1961 to 2022. Results Out of about 350 molecules identified, 43 phenolics, 31 alkaloids, and 28 terpenes were very strongly active against at least one type of RNA virus. These natural products are mainly planar and amphiphilic, with a molecular mass between 200 and 400 g/mol and target viral genome replication. Hydroxytyrosol, silvestrol, lycorine, tylophorine and 12-O-tetradecanoylphorbol 13-acetate with IC50 below 0.01 mu g/mL and selectivity index (S.I.) above 100 have the potential to be used for the development of anti-RNA virus leads. Discussion and conclusions The medicinal plants of Asia and the Pacific are a rich source of natural products with the potential to be developed as lead for the treatment of RNA viral infections.

Item Type: Article
Funders: None
Uncontrolled Keywords: Anti-HIV activity; Human-immunodeficiency-virus; Influenza-A virus; nf-kappa-b; Antiviral activity; In-vitro; Reverse-transcriptase; Japanese encephalitis; Aerial parts; Aids agents
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Nov 2023 08:15
Last Modified: 14 Nov 2023 08:15

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