Prevalence of seizures in brain tumor: A meta-analysis

Audrey, Christine and Lim, Kheng Seang and Ahmad Zaki, Rafdzah and Fong, Si Lei and Chan, Chet-Ying and Kumar, Thinisha Sathis and Narayanan, Vairavan and Tan, Chong -Tin (2022) Prevalence of seizures in brain tumor: A meta-analysis. Epilepsy Research, 187. ISSN 0920-1211, DOI

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Objectives: Prevalence of seizures in brain tumors vary substantially between studies even with similar histo-pathological types. We aimed to identify the seizure prevalence of the commonest types of brain tumors.Methods: Systematic computerized search of PubMed, Embase, and Web of Science were performed. The meta -analysis of pooled prevalence and 95 % confidence interval (CI) for tumor-related seizures were calculated by using a random effect model. Based on the 2014 epilepsy definition, a mean seizure prevalence of 60 % is used to indicate high seizure prevalence in this study.Results: 74 studies that reported seizure prevalence with 23,116 patients were included in this meta-analysis. These tumors has higher seizure incidence rate (at least 60 %) with pooled prevalence of 63 % for adult with low-grade astrocytoma (95 % CI: 57-68 %), 65 % for oligodendroglioma (95% CI: 57-72 %), 72 % for oli-goastrocytoma (95 % CI: 67-77 %), 81 % for ganglioglioma (95 % CI: 66-97 %) and 94 % for DNET (94 % CI: 83-100 %).Conclusion: This study highlights the type of brain tumors that carry a high seizure prevalence. Screening for subtle seizures and early management of seizures may be beneficial in patients with low-grade astrocytoma (adult), oligodendroglioma, oligoastrocytoma, ganglioglioma or DNET brain tumor.

Item Type: Article
Funders: Impact -Oriented Interdisciplinary Research Grant (IIRG) (Grant No: IIRG003-2020HWB)
Uncontrolled Keywords: Brain tumor; Prevalence; Meta-analysis; Systematic review
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine > Medicine Department
Faculty of Medicine > Social & Preventive Medicine
Faculty of Medicine > Surgery Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 22 Nov 2023 07:32
Last Modified: 22 Nov 2023 07:32

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