Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B

Low, Wei Feng and Ngeow, Yun Fong and Chook, Jack Bee and Tee, Kok Keng and Ong, Seng-Kai and Peh, Suat Cheng and Bong, Jan Jin and Mohamed, Rosmawati (2022) Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B. Expert Reviews in Molecular Medicine, 25. ISSN 1462-3994, DOI https://doi.org/10.1017/erm.2022.38.

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Hepatitis B virus (HBV) infection led to 66% liver deaths world-wide in year 2015. Thirty-seven per cent of these deaths were the result of chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Although early diagnosis of HCC improves survival, early detection is rare. Methylation of HBV DNA including covalently closed circular DNA (cccDNA) is more often encountered in HCC cases than those in CHB and cirrhosis. Three typical CpG islands within the HBV genome are the common sites for methylation. The HBV cccDNA methylation affects the viral replication and protein expression in the course of infection and may associate with the disease pathogenesis and HCC development. We review the current findings in HBV DNA methylation that provide insights into its role in HCC diagnosis.

Item Type: Article
Funders: Ministry of Education, Malaysia (Grant No: FRGS/1/2019/SKK08/SYUC/03/2), Sunway Medical Centre (Grant No: SRC/006/2017/FR)
Uncontrolled Keywords: Biomarker; Chronic hepatitis B; Covalently closed circular DNA; CpG islands; Hepatitis B virus; Hepatocellular carcinoma; Methylation
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Faculty of Medicine > Medicine Department
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 23 Nov 2023 02:45
Last Modified: 23 Nov 2023 02:45
URI: http://eprints.um.edu.my/id/eprint/40338

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