Synergistically enhancing the therapeutic effect on cancer, via asymmetric bioinspired materials

Ghahramani, Yasamin and Mokhberi, Marzieh and Mousavi, Seyyed Mojtaba and Hashemi, Seyyed Alireza and Nezhad, Fatemeh Fallahi and Chiang, Wei-Hung and Gholami, Ahmad and Lai, Chin Wei (2022) Synergistically enhancing the therapeutic effect on cancer, via asymmetric bioinspired materials. Molecules, 27 (23). ISSN 1420-3049, DOI

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The undesirable side effects of conventional chemotherapy are one of the major problems associated with cancer treatment. Recently, with the development of novel nanomaterials, tumor-targeted therapies have been invented in order to achieve more specific cancer treatment with reduced unfavorable side effects of chemotherapic agents on human cells. However, the clinical application of nanomedicines has some shortages, such as the reduced ability to cross biological barriers and undesirable side effects in normal cells. In this order, bioinspired materials are developed to minimize the related side effects due to their excellent biocompatibility and higher accumulation therapies. As bioinspired and biomimetic materials are mainly composed of a nanometric functional agent and a biologic component, they can possess both the physicochemical properties of nanomaterials and the advantages of biologic agents, such as prolonged circulation time, enhanced biocompatibility, immune modulation, and specific targeting for cancerous cells. Among the nanomaterials, asymmetric nanomaterials have gained attention as they provide a larger surface area with more active functional sites compared to symmetric nanomaterials. Additionally, the asymmetric nanomaterials are able to function as two or more distinct components due to their asymmetric structure. The mentioned properties result in unique physiochemical properties of asymmetric nanomaterials, which makes them desirable materials for anti-cancer drug delivery systems or cancer bio-imaging systems. In this review, we discuss the use of bioinspired and biomimetic materials in the treatment of cancer, with a special focus on asymmetric nanoparticle anti-cancer agents.

Item Type: Article
Funders: Fundamental Research Grant Scheme (Grant No: FRGS/1/2020/TK0/UM/02/8 & FP023-2020), Global Collaborative Programme-SATU Joint Research Scheme (Grant No: ST004-2021)
Uncontrolled Keywords: Cancer; Bioinspired nanomedicine; Biomimetic materials; Targeted drug delivery; Asymmetry
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 24 Nov 2023 03:53
Last Modified: 24 Nov 2023 03:53

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