Insights on the molecular mechanism of neuroprotection exerted by edible bird's nest and its bioactive constituents

Chu, Weiyi and Phan, Chia Wei and Lim, Seng Joe and Babji, Abdul Salam (2023) Insights on the molecular mechanism of neuroprotection exerted by edible bird's nest and its bioactive constituents. Food Science and Human Wellness, 12 (4). pp. 1008-1019. ISSN 2213-4530, DOI

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Neurodegenerative diseases are often associated with the accumulation of oxidative stress and neuroinflammation. Edible bird's nest (EBN) is a glycoprotein (sialylated mucin glycopeptides) found to be beneficial against neurodegenerative diseases. Antioxidative, anti-inflammatory, and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo models. Functional effects of EBN are often linked to its great number of antioxidants and anti-inflammatory glycopeptides. Bioactive compounds in EBN, especially sialic acid, add value to neurotrophic potential of EBN and contribute to neuronal repair and protection. Various studies reporting the neuroprotective effects of EBN, their molecular mechanisms, and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN.(c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (

Item Type: Article
Funders: Research Excellence Consortium by Ministry of Higher Education, Malaysia (Grant No: KKP/2020/UKM-UKM/5/1), Fundamental Research Grant Scheme (FRGS) (Grant No: FP016- 2019A & FRGS/1/2019/SKK09/UM/02/2)
Uncontrolled Keywords: Antioxidant; Composition; Edible bird nest; Neurodegenerative disease; Neuroprotection; Sialylated mucin glycopeptide
Subjects: R Medicine > R Medicine (General)
S Agriculture > S Agriculture (General)
Divisions: Faculty of Pharmacy > Department of Pharmaceutical Life Sciences
Universiti Malaya Medical Centre (UMMC)
Depositing User: Ms Zaharah Ramly
Date Deposited: 29 Nov 2023 02:09
Last Modified: 29 Nov 2023 02:09

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