Biomimetic hybrid scaffold containing niosomal deferoxamine promotes angiogenesis in full-thickness wounds

Nour, Shirin and Imani, Rana and Mehrabani, Mehrnaz and Solouk, Atefeh and Iranpour, Maryam and Jalili-Firoozinezhad, Sasan and Sharifi, Ali Mohammad (2023) Biomimetic hybrid scaffold containing niosomal deferoxamine promotes angiogenesis in full-thickness wounds. Materials Today Chemistry, 27. ISSN 2468-5194, DOI

Full text not available from this repository.


Effective management of full-thickness wounds faces significant challenges due to poor angiogenesis and impaired healing. Biomimetic tissue-engineered scaffolds with angiogenic properties can, however, enhance the regeneration capacity of the damaged skin. Here, we developed a hybrid double-layer nanofibrous scaffold, comprised of egg white (EW) and polyvinyl alcohol (PVA), loaded with niosomal Deferoxamine (NDFO) for enhanced angiogenesis and wound healing features. The hybrid scaffold showed enhanced mechanical properties with comparable modulus and shape-recovery behavior of the human skin. Thanks to the porous morphology and uniform distribution of NDFO within the nanofibers, in vitro drug release studies indicated controlled and sustained release of DFO for up to 9 days. The constructs also promoted a significant increase in vascular sprouting area in vitro and enhanced vascular branches ex vivo. In vivo, implantation of the hybrid scaffold in full-thickness wounds in rats revealed early angiogenic response, a higher number of neo-formed vessels, a faster healing rate and complete epithelialization as early as day 10, compared to the control groups. Thus, the presented biomimetic hybrid scaffold with DFO control release features holds great promise in accelerated full-thickness wound healing and soft tissue regeneration.(c) 2022 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Skin tissue engineering; Drug delivery; Vascularization; Bioinspired structure
Subjects: R Medicine
Divisions: Faculty of Medicine > Orthopaedic Surgery Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 10 Jul 2023 07:49
Last Modified: 10 Jul 2023 07:49

Actions (login required)

View Item View Item