Determinants and effects of vitamin D supplementation in postmenopausal women: A systematic review

Hassanein, Mohammed M. and Zaman Huri, Hasniza and Baig, Kauser and Abduelkarem, Abduelmula R. (2023) Determinants and effects of vitamin D supplementation in postmenopausal women: A systematic review. Nutrients, 15 (3). ISSN 2072-6643, DOI

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Hormonal fluctuations, excessive clothing covering, sunscreen use, changes in body fat composition, a vitamin D-deficient diet, and a sedentary lifestyle can all predispose postmenopausal women to vitamin D deficiency. An effective supplementation plan requires a thorough understanding of underlying factors to achieve the desired therapeutic concentrations. The objective of this study was to conduct a systematic review of the predictors that affect vitamin D status in postmenopausal women. From inception to October 2022, we searched MEDLINE, Embase, Web of Science, Scopus, and clinical trial registries. Randomized clinical trials of postmenopausal women taking supplements of vitamin D with serum 25-hydroxyvitamin D (25(OH)D) measurement as the trial outcome were included. Two independent reviewers screened selected studies for full-text review. The final assessment covered 19 trials within 13 nations with participants aged 51 to 78. Vitamin D supplementation from dietary and pharmaceutical sources significantly increased serum 25(OH)D to optimal levels. Lower baseline serum 25(OH)D, lighter skin color, longer treatment duration, and prolonged skin exposure were all associated with a better response to vitamin D supplementation in postmenopausal women.

Item Type: Article
Funders: None
Uncontrolled Keywords: Menopause; Vitamin D status; 25-hydroxyvitamin; 1; 25(OH)D; Vitamin D deficiency; Nutrients
Subjects: Q Science > QP Physiology
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Pharmacy > Department of Clinical Pharmacy and Pharmacy Practice
Depositing User: Ms Zaharah Ramly
Date Deposited: 14 Nov 2023 07:23
Last Modified: 03 Dec 2023 02:13

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