Interactomics in plant defence: Progress and opportunities

Mostaffa, Nur Hikmah and Suhaimi, Ahmad Husaini and Al-Idrus, Aisyafaznim (2023) Interactomics in plant defence: Progress and opportunities. Molecular Biology Reports, 50 (5). pp. 4605-4618. ISSN 0301-4851, DOI

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Interactomics is a branch of systems biology that deals with the study of protein-protein interactions and how these interactions influence phenotypes. Identifying the interactomes involved during host-pathogen interaction events may bring us a step closer to deciphering the molecular mechanisms underlying plant defence. Here, we conducted a systematic review of plant interactomics studies over the last two decades and found that while a substantial progress has been made in the field, plant-pathogen interactomics remains a less-travelled route. As an effort to facilitate the progress in this field, we provide here a comprehensive research pipeline for an in planta plant-pathogen interactomics study that encompasses the in silico prediction step to the validation step, unconfined to model plants. We also highlight four challenges in plant-pathogen interactomics with plausible solution(s) for each.

Item Type: Article
Funders: Kementerian Sains, Teknologi dan Inovasi, SF009-2015
Uncontrolled Keywords: AP-MS; Interactomics; Plant-pathogen interaction; Protein-protein interaction; Non-model plants; Y2H
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms Zaharah Ramly
Date Deposited: 27 Nov 2023 03:06
Last Modified: 27 Nov 2023 03:06

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