Propranolol ameliorates the antifungal activity of azoles in invasive candidiasis

Mayandi, Venkatesh and Kang, Wen-Tyng and Ting, Darren Shu Jeng and Goh, Eunice Tze Leng and Lynn, Myoe Naing and Aung, Thet Tun and Vadivelu, Jamuna and Barathi, Veluchamy Amutha and Chan, Anita Sook Yee and Lakshminarayanan, Rajamani (2023) Propranolol ameliorates the antifungal activity of azoles in invasive candidiasis. Pharmaceutics, 15 (4). ISSN 1999-4923,

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The effectiveness of current antifungal therapies is hampered by the emergence of drug resistance strains, highlighting an urgent need for new alternatives such as adjuvant antifungal treatments. This study aims to examine the synergism between propranolol and antifungal drugs, based on the premise that propranolol is known to inhibit fungal hyphae. In vitro studies demonstrate that propranolol potentiates the antifungal activity of azoles and that the effect is more pronounced for propranolol-itraconazole combination. Using an in vivo murine systemic candidemia model, we show that propranolol-itraconazole combination treatment resulted in a lower rate of body weight loss, decreased kidney fungal bioburden and renal inflammation when compared to propranolol and azole treatment alone or untreated control. Altogether, our findings suggest that propranolol increases the efficacy of azoles against C. albicans, offering a new therapeutic strategy against invasive fungal infections.

Item Type: Article
Uncontrolled Keywords: Antifungal therapies; Synergism; Propranolol-itraconazole; Candida albicans
Subjects: R Medicine
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 16 May 2024 04:34
Last Modified: 16 May 2024 04:34

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