Antioxidant biomaterials in cutaneous wound healing and tissue regeneration: A critical review

Fadilah, Nur Izzah Md and Phang, Shou Jin and Kamaruzaman, Nurkhuzaiah and Salleh, Atiqah and Zawani, Mazlan and Sanyal, Arka and Maarof, Manira and Fauzi, Mh Busra (2023) Antioxidant biomaterials in cutaneous wound healing and tissue regeneration: A critical review. Antioxidants, 12 (4). ISSN 2076-3921, DOI

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Natural-based biomaterials play an important role in developing new products for medical applications, primarily in cutaneous injuries. A large panel of biomaterials with antioxidant properties has revealed an advancement in supporting and expediting tissue regeneration. However, their low bioavailability in preventing cellular oxidative stress through the delivery system limits their therapeutic activity at the injury site. The integration of antioxidant compounds in the implanted biomaterial should be able to maintain their antioxidant activity while facilitating skin tissue recovery. This review summarises the recent literature that reported the role of natural antioxidant-incorporated biomaterials in promoting skin wound healing and tissue regeneration, which is supported by evidence from in vitro, in vivo, and clinical studies. Antioxidant-based therapies for wound healing have shown promising evidence in numerous animal studies, even though clinical studies remain very limited. We also described the underlying mechanism of reactive oxygen species (ROS) generation and provided a comprehensive review of ROS-scavenging biomaterials found in the literature in the last six years.

Item Type: Article
Funders: UKM Fundamental Grant, Faculty of Medicine (GFFP) (FF-2022-310)
Uncontrolled Keywords: Antioxidant; Biomaterials; Wound healing; Oxidative stress; Delivery system
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Biomedical Science Department
Depositing User: Ms Zaharah Ramly
Date Deposited: 06 Jul 2023 03:41
Last Modified: 06 Jul 2023 03:41

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