Avian influenza virus tropism in humans

AbuBakar, Umarqayum and Amrani, Lina and Kamarulzaman, Farah Ayuni and Karsani, Saiful Anuar and Hassandarvish, Pouya and Khairat, Jasmine Elanie (2023) Avian influenza virus tropism in humans. Viruses-Basel, 15 (4). ISSN 1999-4915, DOI https://doi.org/10.3390/v15040833.

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An influenza pandemic happens when a novel influenza A virus is able to infect and transmit efficiently to a new, distinct host species. Although the exact timing of pandemics is uncertain, it is known that both viral and host factors play a role in their emergence. Species-specific interactions between the virus and the host cell determine the virus tropism, including binding and entering cells, replicating the viral RNA genome within the host cell nucleus, assembling, maturing and releasing the virus to neighboring cells, tissues or organs before transmitting it between individuals. The influenza A virus has a vast and antigenically varied reservoir. In wild aquatic birds, the infection is typically asymptomatic. Avian influenza virus (AIV) can cross into new species, and occasionally it can acquire the ability to transmit from human to human. A pandemic might occur if a new influenza virus acquires enough adaptive mutations to maintain transmission between people. This review highlights the key determinants AIV must achieve to initiate a human pandemic and describes how AIV mutates to establish tropism and stable human adaptation. Understanding the tropism of AIV may be crucial in preventing virus transmission in humans and may help the design of vaccines, antivirals and therapeutic agents against the virus.

Item Type: Article
Uncontrolled Keywords: Influenza A virus; Avian influenza virus; Virus tropism in humans; Antiviral; vaccine
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculty of Science > Institute of Biological Sciences
Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre
Depositing User: Ms Zaharah Ramly
Date Deposited: 23 Jun 2023 07:13
Last Modified: 23 Jun 2023 07:13
URI: http://eprints.um.edu.my/id/eprint/38320

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